Grey's Anatomy
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92 free Grey's Anatomy trivia questions with answers — entertainment quiz, new questions added Oct 2026.
71 free Grey's Anatomy trivia questions with answers. Are you a true Grey's Anatomy superfan? Put your knowledge of Grey Sloan Memorial Hospital to the test with our exciting trivia quiz. From memorable character moments to plot twists, discover how well you really know this beloved medical drama series.
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Q 01Who is the creator and executive producer of the television series Grey's Anatomy?
Shonda Rhimes
Shonda Rhimes says she was obsessed with televised surgery, so when ABC asked her for another pilot the operating room seemed the natural setting.
Q 02Like her mother before her, Meredith Grey specialises in which branch of surgery on Grey's Anatomy?
General Surgery
General Surgery made Ellis Grey's name, and when Miranda Bailey took over as chief in Season 12 she promoted Meredith to run the department.
Q 03Which nickname do the interns give Derek Shepherd in the first season of Grey's Anatomy?
McDreamy
McDreamy caught on so well that the interns kept minting 'Mc' names: when Meredith later dated a vet, he became McVet.
Q 04Which cancer is Izzie Stevens diagnosed with in Season 5 of Grey's Anatomy?
Melanoma
Melanoma: Izzie's visions of her dead fiancé Denny turn out to be a symptom, because the cancer has already spread to her brain.
Q 05Cristina Yang leaves Grey's Anatomy in Season 10 to run a research hospital in which city?
Zurich
Zurich: the fiancé who once jilted her runs a research hospital there, and he hands Cristina his job so that he can move away with his family.
Q 06What is the nickname of Miranda Bailey's son, born during Season 2?
Tuck
Tuck: Bailey's son William George Bailey Jones, delivered in Season 2 with George O'Malley's help, is nicknamed Tuck after his father, Tucker Jones.
Q 07What neurological condition did Ellis Grey suffer from?
Alzheimer's Disease
Alzheimer's Disease, early-onset, is what made Meredith a doctor: she was called home from Europe to care for Ellis, and the diagnosis pushed her into medical school.
Q 08Which character was the Head of Orthopedic Surgery at Grey Sloan Memorial Hospital?
Callie Torres
Callie Torres arrives in Season 2 as the orthopedic surgeon who falls for George O'Malley, and the pair impulsively marry in Las Vegas a season later.
Q 09In which surgical specialty is Jackson Avery's mother, Catherine, renowned?
Urology
Urology: Catherine makes her entrance in Season 8 by arriving to perform what the show bills as the first penis transplant in the United States.
Q 10Which show did Grey's Anatomy overtake in 2019 as America's longest-running primetime medical drama?
ER
ER ended in 2009 after 331 episodes; Grey's Anatomy, first scheduled for a four-week tryout, passed it with its 332nd episode in February 2019.
Q 11Which actor plays George O'Malley on Grey's Anatomy?
T.R. Knight
T.R. Knight left after five seasons, yet returned in 2020 when George appears to a gravely ill Meredith on a dream beach and the two talk over his death.
Q 12Which Snow Patrol song plays in the Season 2 finale of Grey's Anatomy?
Chasing Cars
Chasing Cars was heard during an emotional scene in the May 2006 finale, and the exposure pushed the song onto the US download and pop charts.
Q 13Which two Mercy West transfers are killed in the Season 6 hospital shooting on Grey's Anatomy?
Reed Adamson and Charles Percy
Q 21How did Izzie Stevens pay her way through medical school?
Modeling
Modeling paid Izzie's bills through medical school, and the work comes back to haunt her in Season 1 when Alex Karev exposes her old lingerie ads to their colleagues.
Q 22In a Season 2 train-crash episode of Grey's Anatomy, two strangers arrive impaled on the same what?
Metal pole
Metal pole: the surgeons cannot save both, because the only way to operate is to slide one patient off the pole, which will almost certainly kill them.
Q 23What crime puts Meredith Grey's medical licence at risk in Season 16 of Grey's Anatomy?
Insurance fraud
Insurance fraud: Meredith broke the law to get an uninsured patient treated, and a colleague took the blame until she turned herself in and was sentenced to community service.
Reed Adamson and Charles Percy: Reed is killed outright, while Charles dies in Miranda Bailey's arms because the lifts are shut off and she cannot get him to an operating room.
Q 14In Season 5 of Grey's Anatomy, what do Meredith and Derek write their wedding vows on?
A Post-it note
A Post-it note: the couple had given their planned ceremony to Izzie and Alex and could not reach City Hall in time, so they signed their vows on a sticky note instead.
Q 15Which spin-off followed Addison Montgomery after she left Seattle for California?
Private Practice
Private Practice was launched from inside its parent show: a two-part Season 3 episode sent Addison to a California clinic as a trial run for the new series.
Q 16Why does George O'Malley repeat his intern year on Grey's Anatomy?
He failed his exam by one point
He failed his exam by one point, as Lexie Grey later found out; armed with that, George confronted the Chief, won an early retake and passed.
Q 17Which surgeon does Callie Torres marry in the Grey's Anatomy episode 'White Wedding'?
Arizona Robbins
Arizona Robbins and Callie marry in a garden ceremony led by Miranda Bailey, though Callie's mother refuses to attend because her daughter is marrying a woman.
Q 18Where do the doctors of Grey's Anatomy drink after work, across the street from the hospital?
Joe's Bar
Joe's Bar, officially the Emerald City Bar, is where Meredith picks up a stranger the night before her first day, only to find he is one of her new bosses.
Q 19Where does Derek Shepherd propose to Meredith in Season 5 of Grey's Anatomy?
In a hospital elevator
In a hospital elevator: Derek covers its walls with scans from the surgeries the two of them have worked on together, then asks her to marry him.
Q 20Zola, the baby Meredith and Derek adopt on Grey's Anatomy, was born with which condition?
Spina Bifida
Spina Bifida is why six-month-old Zola was flown from Malawi to Seattle with a group of children needing surgery, which is how the couple came to meet her.
Q 24Which Grey's Anatomy surgeon has a large brain tumor removed in Season 14?
Amelia Shepherd
Amelia Shepherd, a brain surgeon herself, learns the tumor has been growing for years, and that it may explain a decade of her most reckless decisions.
Q 25What was Cristina Yang's primary surgical specialty?
Cardiothoracic Surgery
Cardiothoracic Surgery took Cristina away from Seattle after the plane crash, to a heart fellowship at the Mayo Clinic, before she came back.
Q 26Which actress plays Meredith Grey?
Ellen Pompeo
Ellen Pompeo led the cast from the 2005 pilot, then scaled back in Season 19 to eight episodes while staying on as narrator and executive producer.
Q 27Which guest star played bomb squad leader Dylan Young in Season 2 of Grey's Anatomy?
Kyle Chandler
Kyle Chandler earned an Emmy nomination for the two-part story, in which his character takes the explosive from Meredith and is killed when it goes off moments later.
Q 28How does George O'Malley die on Grey's Anatomy?
He is hit by a bus
He is hit by a bus while pushing a stranger out of its path, and is so badly hurt that his own friends treat him as a John Doe until he traces a clue on Meredith's palm.
Q 29On Grey's Anatomy, what is Izzie Stevens's patient and fiancé Denny Duquette waiting for?
A heart transplant
A heart transplant: Denny finally receives his new heart, only to die of a stroke hours later, on the day Izzie accepted his proposal.
Q 30What was Addison Montgomery's primary surgical specialty when she first arrived?
Neonatal surgery
Neonatal surgery: Addison flew in from New York at Richard Webber's request to help with a case, and her arrival was how Meredith learned Derek was still married.