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50 free My Sister's Keeper trivia questions with answers — literature quiz, new questions added Aug 2026.
Jodi Picoult's story of the Fitzgerald family asks a question with no comfortable answer: can a child conceived to keep her sister alive ever say no? Anna's lawsuit against her own parents made the novel a book-club fixture, and the 2009 film brought the courtroom and the hospital ward to a far wider audience, though not without a famous row over how it should finish. These 50 questions cover the novel's plot and characters, the legal fight at its centre, the choices the film made with its cast and its conclusion, how Picoult came to write the book, and what critics and librarians made of it. It suits book clubs, English classes and anyone who read it in one sitting and still thinks about the last chapter. Play it on screen or print it for the table.
30 of 50 questions with answers and explanations. Play the quiz
Q 01Conceived through IVF as a tissue match for her sister Kate, Anna Fitzgerald is what kind of child?
A savior sibling
A savior sibling is conceived to provide stem cells or marrow for a sick brother or sister; the first real case, Adam Nash, was born in 2000. Anna gives blood, marrow and more as Kate relapses.
Q 02In Picoult's novel, what kills Anna Fitzgerald on the drive back from court after winning her case?
A truck hitting the car
A truck hitting the car leaves Anna brain-dead, and lawyer Campbell Alexander approves the organ donation that saves Kate. The epilogue follows the family eight years on.
Q 03How does the 2009 film of My Sister's Keeper end for the two sisters, compared with Picoult's novel?
Kate dies and Anna lives
Kate dies and Anna lives in the film, the reverse of the novel; Kate slips away in her sleep with Sara beside her once the family accepts she is ready. Anna's voice-over says she was born because she had a sister.
Q 04Which director of The Notebook and John Q. made the 2009 film My Sister's Keeper?
Nick Cassavetes
Nick Cassavetes is the son of director John Cassavetes and actress Gena Rowlands, and he appeared uncredited in his father's 1970 film Husbands.
Q 05Jodi Picoult has said she regretted letting the director of My Sister's Keeper do what?
Change the ending
To change the ending was the one alteration Picoult publicly regretted; the film also expanded some subplots and eliminated others entirely, against her wishes.
Q 06Which There's Something About Mary star plays the mother, Sara Fitzgerald, in the 2009 adaptation?
Cameron Diaz
Cameron Diaz won the ALMA for Outstanding Actress in a Motion Picture for the role, in which Sara has given up practising law to care for Kate.
Q 07Which Little Miss Sunshine Oscar nominee plays Anna Fitzgerald in the 2009 adaptation?
Abigail Breslin
Abigail Breslin was ten when her Olive Hoover earned an Oscar nomination for Best Supporting Actress; critic James Berardinelli praised the natural bond she and her screen sister showed.
Q 08Which sister act was cast as Kate and Anna Fitzgerald before the elder balked at shaving her head?
Dakota and Elle Fanning
Dakota and Elle Fanning both left the project in February 2008, and Variety announced their replacements that same month.
Q 09Anna Fitzgerald hires lawyer Campbell Alexander to sue her parents for what legal status?
Medical emancipation
Medical emancipation would let Anna make her own treatment decisions, including whether to give Kate a kidney; when she wins, the judge hands Campbell medical power of attorney.
Q 10Cross-examined by Sara in the 2009 adaptation, what does Anna Fitzgerald admit about her lawsuit?
Kate asked her to refuse
Kate asked her to refuse the kidney, knowing she would not survive another operation and having had enough of the family's suffering; Jesse's intervention at the hearing forces the admission.
Q 11Jodi Picoult set the Fitzgeralds' story in the fictional town of Upper Darby, in which US state?
Rhode Island
Rhode Island is where Picoult, who is based in Hanover, New Hampshire, placed the invented town; the story unfolds there in 2004.
Q 12What is the full first name of Anna Fitzgerald, the youngest Fitzgerald child in Picoult's novel?
Andromeda
Andromeda suits a family whose father Brian is fond of astronomy; Anna was meant to make a single donation at birth before Kate's relapses changed that.
Q 13Why does lawyer Campbell Alexander secretly need his service dog in Picoult's novel?
He has epilepsy
Q 21Which actress, Ariel DuBois on the TV series Medium, plays Kate Fitzgerald in the 2009 adaptation?
Sofia Vassilieva
Sofia Vassilieva, the only child of Russian immigrants, had already played Eloise in two TV movies opposite Julie Andrews before Medium.
Q 22Which 30 Rock star plays Anna's lawyer, Campbell Alexander, in the 2009 film My Sister's Keeper?
Alec Baldwin
Alec Baldwin won two Emmys as Jack Donaghy, and his Campbell files a suit for partial termination of the Fitzgeralds' parental rights on Anna's behalf.
Q 23Which twice Oscar-nominated actress, for Working Girl and In & Out, plays Judge De Salvo on screen?
Joan Cusack
He has epilepsy, developed after a concussion, and it is why he left Julia Romano years earlier, believing she deserved better; a seizure during the trial exposes the secret.
Q 14Julia Romano, Campbell Alexander's high-school girlfriend, is appointed to Anna's case in what role?
Guardian ad litem
A guardian ad litem is appointed to represent a child's best interests in court; Judge DeSalvo chooses Julia because Anna and Sara cannot be in the same room during the trial.
Q 15What loss, suffered the year before Anna's case, shapes Judge DeSalvo in Picoult's novel?
His daughter, to a drunk driver
His daughter, to a drunk driver, when she was 12, so he too is a parent who has buried a child by the time Anna's petition reaches his court.
Q 16Sara Fitzgerald, once a civil attorney, responds to Anna's lawsuit in Picoult's novel by doing what?
Representing herself
Representing herself, Sara at first assumes Anna merely wants attention and expects the complaint to be withdrawn; Anna will not back down.
Q 17Jesse Fitzgerald, the overlooked eldest child, spends his time in Picoult's novel doing what?
Setting fires in empty buildings
Setting fires in empty buildings with homemade explosives, and using drugs, is how Jesse acts out after years of being ignored in favour of Kate and Anna; the epilogue makes him a police officer.
Q 18In the epilogue of Picoult's novel, eight years after the trial, what has Kate Fitzgerald become?
A ballet teacher
A ballet teacher, Kate also narrates the final pages, speaking of deep guilt and of a bond with the part of Anna she carries inside her.
Q 19What does Sara hide from Kate about Taylor Ambrose, the boyfriend Kate met during chemotherapy?
That he has died
That he has died is hidden by Sara, who fears the grief would rob Kate of her will to live; Kate assumes Taylor simply stopped calling, and the rift with her mother deepens when she learns the truth.
Q 20How is wealthy aunt Suzanne, who openly criticises Sara's treatment of both girls, related to Sara?
Her older sister
Her older sister by ten years, Suzanne shows Anna more support than Brian does, and the 2009 film renames the aunt Kelly.
Joan Cusack later won a Primetime Emmy for playing Sheila Jackson on Shameless; the novel's Judge De Salvo is a man, while the film's is Judge Joan De Salvo.
Q 24Which star of The Lost Boys and Speed 2 plays the father, Brian Fitzgerald, in the 2009 adaptation?
Jason Patric
Jason Patric is the grandson of Jackie Gleason and the son of Jason Miller, whose play That Championship Season won a Pulitzer Prize.
Q 25Which Sarah Connor Chronicles star plays Kate Fitzgerald's boyfriend, Taylor Ambrose, on screen?
Thomas Dekker
Thomas Dekker played John Connor on that series and Zach on Heroes; in the film, Taylor and Kate attend a hospital prom for teen patients shortly before his death.
Q 26Which Bones star plays Dr. Farquad, one of Kate Fitzgerald's doctors, in the 2009 adaptation?
Emily Deschanel
Emily Deschanel's father, Caleb Deschanel, shot the film as its cinematographer; her younger sister is the actress and singer Zooey Deschanel.
Q 27Which film topped the US box office the weekend My Sister's Keeper opened fifth, in June 2009?
Revenge of the Fallen
Transformers: Revenge of the Fallen led, and The Proposal, The Hangover and Up were also ahead of Keeper's $12,442,212 opening weekend.
Q 28Which Randy Newman song, sung by Edwina Hayes, opens the My Sister's Keeper soundtrack album?
Feels Like Home
Feels Like Home leads a soundtrack that also carries Regina Spektor's Better and Pete Yorn's Don't Wanna Cry.
Q 29Which Bridge to Terabithia and The Proposal composer also scored the 2009 film My Sister's Keeper?
Aaron Zigman
Aaron Zigman, born in San Diego, wrote his first film score for John Q. in 2002 and has co-written songs with Quincy Jones and John Legend.
Q 30My Sister's Keeper's director drew on his child Sasha's health history; she was born with what?
A heart defect
A heart defect that required substantial surgery; he had already dedicated his 2002 film John Q. to Sasha.