The Binding of Isaac
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50 free The Binding of Isaac trivia questions with answers — trivia quiz, new questions added Oct 2026.
The Binding of Isaac began as a small side project in 2011 and grew into one of the most replayed roguelikes ever made. A frightened boy flees into the cellar beneath his house, and every run rebuilds that dungeon from scratch, with hundreds of items that stack into wild combinations and a story that only comes into focus after many endings. This quiz covers the whole series, from the original game to the Rebirth remake and its expansions. Expect questions on the story and its Old Testament roots, famous items and what they do, playable characters and how they are unlocked, bosses and floors, and the people who made the game. It is written for players, whether you have a handful of runs behind you or a save file full of completion marks. Item questions describe what an item does instead of showing its sprite, so the effects are what you need to remember, and every answer comes with a short explanation.
30 of 50 questions with answers and explanations. Play the quiz
Q 01What does Isaac fire like bullets at monsters in The Binding of Isaac, in the style of a twin-stick shooter?
Tears
Tears are Isaac's basic shots, and the items he collects can replace them with lasers, guided missiles or a thrown knife.
Q 02In the Book of Genesis story that gives The Binding of Isaac its title, which patriarch is ordered to sacrifice his son?
Abraham
Abraham binds his son on an altar before an angel stops him, and the game recasts him as a mother who hears a voice from above.
Q 03Which classic game's dungeon structure did Edmund McMillen reuse for the room-by-room floors of The Binding of Isaac?
The Legend of Zelda
The Legend of Zelda shaped the game so directly that the physical Switch edition came with a manual modelled on the Nintendo original's.
Q 04Which sandbox hit beat The Binding of Isaac to Best Independent Game at the 2011 Spike Video Game Awards?
Minecraft
Minecraft took the prize in a year when Edmund McMillen had expected his odd little game to sell only a few hundred copies.
Q 05Nintendo blocked a 3DS port of The Binding of Isaac in 2012 after objecting to which aspect of the game?
Religious content
Religious content was the reason given, yet three Nintendo staff championed the remake and it reached the company's consoles in 2015.
Q 06Four playable characters in The Binding of Isaac were modelled on the fighter, thief, cleric and wizard of which game?
Dungeons & Dragons
Dungeons & Dragons was among the pastimes that some of Edmund McMillen's devout relatives condemned, a family rift that fed the game's story.
Q 07Missing No., an item that scrambles Isaac's items in The Binding of Isaac, is named after a glitch in which series?
Pokémon
Pokémon's MissingNo. glitch garbles graphics and item counts in Red and Blue, chaos the item echoes by rerolling Isaac's items and stats.
Q 08Which figure from Alpine Christmas folklore appears as a mini-boss in The Binding of Isaac, dropping A Lump of Coal?
Krampus
Krampus punishes naughty children in the folklore, which is why coal sits in the item pool of the game's version.
Q 09Which infamous group supplies the mini-bosses of The Binding of Isaac, each one dropping its own specific rewards?
The seven deadly sins
The seven deadly sins also have much stronger alternative versions, which cannot appear during the first chapter of a run.
Q 10Which character in The Binding of Isaac: Rebirth starts with an extra life and returns stronger after his first death?
Lazarus
Lazarus revives in a Risen form with above-average damage, speed and range, a nod to the man Jesus raised from the dead.
Q 11How does Isaac escape his locked bedroom at the start of The Binding of Isaac as his mother bursts in?
Down a trapdoor
Down a trapdoor hidden under his rug is the way out, and every new run is assumed to begin the moment he jumps.
Q 12Which book falls from a shelf and strikes Isaac's mother in the ending after The Binding of Isaac's Mom fight?
The Bible
The Bible is also an item that kills Mom instantly when Isaac uses it during her fight, a nod to this ending.
Q 13In the Genesis story behind The Binding of Isaac's title, which animal ends up sacrificed in the boy's place?
A ram
A ram appears and is offered instead, though the game's Isaac gets no such rescue and has to flee on his own.
Q 21Which item in The Binding of Isaac swaps Isaac's shots for a charged blood laser that pierces every enemy?
Brimstone
Brimstone's beam passes straight through obstacles too, hitting everything in its path once a short charge-up is finished.
Q 22Which item in The Binding of Isaac makes Isaac lob explosive, poisonous shots in an arc at a slow rate?
Ipecac
Ipecac is named after syrup of ipecac, a powerful emetic that was used to make people vomit.
Q 23Which Binding of Isaac item, a nod to Greek myth, trades a slower fire rate for a massive boost to damage?
Polyphemus
Polyphemus is named after the Cyclops of Homer's Odyssey, and a shot that kills an enemy flies on with its leftover damage.
Q 14Which software platform, whose limits blocked a second expansion, was the original 2011 The Binding of Isaac built in?
Adobe Flash
Adobe Flash let the pair build it quickly, but its creator later said he would never have used it had he known anyone would care.
Q 15Which other Edmund McMillen game's villain inspired Dr. Fetus, the explosive-firing item in The Binding of Isaac?
Super Meat Boy
Super Meat Boy's sales also bankrolled the risk, leaving Edmund McMillen free to make a game he feared could be career suicide.
Q 16Which company at first rejected the mobile port of The Binding of Isaac: Rebirth, citing violence towards children?
Apple
Apple refused the game in 2016, then worked with the publisher on preapproval before an iOS version arrived in January 2017.
Q 17Which crowdfunding site funded the card game The Binding of Isaac: Four Souls within 90 minutes of its 2018 launch?
Kickstarter
Kickstarter backers passed the $50,000 goal within 90 minutes and went on to pledge more than $2.6 million.
Q 18Which pickup do players normally spend to get into the hidden Secret Room on each floor of The Binding of Isaac?
Bombs
Bombs set against the right wall open the room, which usually sits beside three or four other rooms on the map.
Q 19What is the roguelike rule called that ends a run of The Binding of Isaac for good when Isaac loses every heart?
Permadeath
Permadeath sends the player back to a freshly generated dungeon, though Rebirth at least lets a run be saved and resumed midway.
Q 20Which kind of fan uploads did Edmund McMillen credit for The Binding of Isaac's sudden surge in sales?
Let's Play videos
Let's Play videos turned a game selling a few hundred copies a day into a hit that passed a million sales by November 2012.
Q 24The Ludovico Technique, a Binding of Isaac item that gives Isaac one steerable shot, takes its name from which novel?
A Clockwork Orange
A Clockwork Orange has its narrator's eyelids forced open during the treatment, an image the item turns into one controlled, hovering shot.
Q 25Collecting three items tied to which pet cat turns Isaac into a flying, fly-spawning form in The Binding of Isaac?
Guppy
Guppy was Edmund McMillen's first cat in real life, and the pet's head, paw, tail and collar all appear as items that count toward the change.
Q 26Which tarot card in The Binding of Isaac teleports Isaac back to the starting room of the floor he is on?
The Fool
The Fool is numbered zero in the game's tarot deck, a fitting ticket back to the spot where each floor begins.
Q 27Which item in The Binding of Isaac grants a shield that cancels the first hit Isaac takes in every room?
Holy Mantle
Holy Mantle belongs to the Seraphim set, and collecting three items from that set transforms Isaac into an angel.
Q 28Which dice item, which Isaac himself starts with once unlocked, rerolls every item in the room in The Binding of Isaac?
The D6
The D6 was simply called The Dice in the original game, where it recharged twice as fast as it does in Rebirth.
Q 29Which type of collectible, held in its own slot, did the Wrath of the Lamb expansion add to The Binding of Isaac?
Trinkets
Trinkets give subtle passive bonuses and normally only one can be carried, and the expansion that introduced them shipped with 33.
Q 30Which optional area can open after a boss fight in The Binding of Isaac, selling powerful items for heart containers?
Devil Room
Devil Room deals carry a hidden price beyond health, because paying for one normally stops the rival Angel Room from appearing.