10 free Incurable Illnesses trivia questions with answers — science & nature quiz, new questions added Aug 2026.
Here's a sobering fact: over 7,000 rare diseases affect millions worldwide, and most have no known cure. Ready to test your medical knowledge? This quiz separates the informed from the guessing.
All 10 questions with answers and explanations. Play the quiz
Q 01Which neurodegenerative disorder accounts for around 60 to 70 percent of dementia cases?
Alzheimer's Disease
The strongest genetic risk factor is a variant of apolipoprotein E, a protein involved in fat metabolism; a definitive diagnosis is still only possible by examining brain tissue after death.
Q 02Which autoimmune disorder attacks the wrists and hands symmetrically on both sides?
Rheumatoid Arthritis
Unlike wear-and-tear arthritis, the pain and stiffness typically get worse after rest rather than after activity.
Q 03Which long-term inflammatory airway disease causes recurring wheezing and chest tightness?
Asthma
Aspirin and beta blockers are among the medications that can trigger an attack in susceptible people.
Q 04Which autoimmune condition destroys the insulin-producing beta cells of the pancreas?
Type 1 Diabetes
Because no insulin is produced, blood sugar cannot be stored or converted into energy, and symptoms such as constant thirst and frequent urination usually appear within weeks.
Q 05Which autosomal recessive disorder is diagnosed with a sweat test because sufferers have unusually salty sweat?
Cystic Fibrosis
A faulty CFTR protein turns normally thin secretions thick, clogging the lungs and inviting bacteria such as Pseudomonas aeruginosa to colonise them.
Q 06Which retrovirus can progress, untreated, to acquired immunodeficiency syndrome?
HIV
A person on long-term treatment with an undetectable viral load has effectively no risk of passing it on sexually, a message campaigns summarise as Undetectable = Untransmittable.
Q 07Which condition is caused by the loss of dopamine-producing neurons in the substantia nigra?
Parkinson's Disease
Non-motor signs such as a fading sense of smell and sleep disturbances can appear years before the familiar tremor.
Q 08Which widespread-pain condition, affecting 2 to 4 percent of people, was only formally defined in 1990?
Fibromyalgia
Its causes remain unknown, and women are affected at a higher rate than men.
Q 09Which inflammatory bowel disorder can affect any part of the GI tract and raises colorectal cancer risk?
Crohn's Disease
Despite being immune-related, it does not appear to be a true autoimmune disease; the immune system seems to be targeting gut microbes rather than the body itself.
Q 10In which autoimmune disease does the immune system attack myelin, causing double vision and poor coordination?
Multiple Sclerosis
It is classed as a demyelinating disease because the damage disrupts the nervous system's ability to transmit signals.