House M.D. Trivia
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189 free House M.D. trivia questions with answers — entertainment quiz, new questions added Oct 2026.
40 free House M.D. trivia questions with answers. House M.D. was the most-watched TV show on Earth in 2008, and this quiz treats it accordingly. Forty questions cover Dr. Gregory House and his team at Princeton-Plainsboro, the Sherlock Holmes homages hidden in plain sight, the Vicodin, the cane, the whiteboard, the guest villains, the bus crash, the psychiatric hospital, the prison, and the finale that sent House and Wilson off on motorcycles. It starts with House MD trivia any fan can answer and works up to the production stories: the audition tape shot in a hotel bathroom, the director who thought Hugh Laurie was American, and why Kutner had to die. Difficulty ratings are shown so you can pick your battles. Every answer was checked against Wikipedia's articles on the series, its characters and episodes, and each question carries its source.
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Q 01On which network did House air from 2004 to 2012?
Fox
House aired on Fox for eight seasons and 177 episodes, from November 16, 2004 to May 21, 2012.
Q 02Who created House?
David Shore
David Shore created House and served as its showrunner for all eight seasons; he gave the misanthropic hero his voice and directed the series finale himself.
Q 03At which fictional teaching hospital is House set?
Princeton-Plainsboro
Princeton-Plainsboro Teaching Hospital is fictional; its interiors were shot on sound stages at the Fox lot in Century City, Los Angeles.
Q 04What is House's medical double specialty?
Infectious disease and nephrology
House is double board-certified in infectious disease and nephrology, and heads Princeton-Plainsboro's Department of Diagnostic Medicine.
Q 05Which painkiller is House dependent on?
Vicodin
The season eight premiere is titled Twenty Vicodin, after the stash he needs to get through his last days in prison.
Q 06What caused the damage to House's right leg?
An infarction in his thigh muscle
An infarction in his thigh muscle: an aneurysm clotted during a golf game, was misdiagnosed for days, and Stacy authorised removing the dead muscle while he was in a coma.
Q 07What is the street address of House's apartment?
221B Baker
House lives at 221B Baker Street, a deliberate nod to Sherlock Holmes's London address; the creator called House's own name a homage to Holmes, with Wilson as his Watson.
Q 08Under what name is the gunman who shoots House in the season two finale credited?
Moriarty
The shooter in No Reason is credited only as Moriarty, after Holmes's nemesis; most of the episode is a hallucination House has while unconscious.
Q 09Which hospital department does House's only real friend, Dr. James Wilson, head?
Oncology
Oncology head James Wilson is played by Robert Sean Leonard; the friendship echoes Holmes and Watson and carries the whole final episode.
Q 10What is Dr. Lisa Cuddy's job at the hospital?
Dean of Medicine
Dean of Medicine and chief administrator; Lisa Edelstein left the show after season seven when a salary cut was proposed.
Q 11Which member of House's original team is a neurologist?
Foreman
Omar Epps's character had a juvenile record for burglary, which is partly why House hired him; he ends the series as Dean of Medicine.
Q 12Which actress plays immunologist Dr. Allison Cameron?
Jennifer Morrison
Jennifer Morrison played Cameron from the pilot through season six and returned for the finale; Jesse Spencer, who plays Chase, later moved on to Chicago Fire.
Q 13Which genetic condition does Thirteen inherit from her mother?
Huntington's
Thirteen, Dr. Remy Hadley, tests positive for Huntington's disease in season four, the illness that killed her mother; her nickname came from her number in House's hiring contest.
Q 21Which episode drew the show's biggest audience, 29 million, after airing straight after Super Bowl XLII?
Frozen
Frozen aired on February 3, 2008 straight after Super Bowl XLII and drew about 29 million viewers; Mira Sorvino guest-starred as a psychiatrist trapped at the South Pole, diagnosed over a video link.
Q 22Which billionaire, played by Chi McBride, tries to fire House in season one?
Edward Vogler
Edward Vogler, a pharmaceutical mogul who buys his way onto the hospital board, appears in five season-one episodes before the board chooses House over his money.
Q 23Why does Detective Michael Tritter, played by David Morse, pursue the doctor in season three?
He was left with a rectal thermometer
Q 14Why was Dr. Kutner written out of the show in season five?
Kal Penn joined the Obama White House
The character is found dead of a self-inflicted gunshot in the episode Simple Explanation, and returns as a hallucination in the finale.
Q 15Which member of the later team is a former plastic surgeon?
Taub
Taub, played by Peter Jacobson, left a lucrative plastic surgery practice before joining House's team; House exploits his marriage troubles and the two daughters he fathers with different women.
Q 16How did House recruit his new team in season four?
Through a reality-show style elimination contest
He starts with 40 applicants and numbers them rather than learning names; the show called it its own version of Survivor.
Q 17Which Massive Attack song is the show's opening theme in the United States?
Teardrop
Teardrop, from Massive Attack's 1998 album Mezzanine, opens US episodes; rights issues meant many international broadcasts used different theme music.
Q 18Where did Hugh Laurie record his audition tape for House?
A hotel bathroom in Namibia
Laurie taped it in a hotel bathroom in Namibia while shooting Flight of the Phoenix there in 2004, apologising on the tape for the poor lighting.
Q 19Which director of the pilot did not realise Hugh Laurie was English?
Bryan Singer
Singer had reportedly said he wanted an American for the part; Laurie credits his accent to a misspent youth watching too many movies.
Q 20In which year was House the most-watched television programme in the world?
2008
Eurodata TV Worldwide, which tracks ratings across dozens of countries, named House the most-watched television programme in the world for 2008.
The vendetta ends with House in court over forged prescriptions and Cuddy perjuring herself to save him.
Q 24Which actress plays Stacy Warner, House's ex-girlfriend, in seasons one and two?
Sela Ward
Sela Ward played Stacy Warner, a lawyer who authorised the leg surgery that ended their relationship and returns in season two as the hospital's counsel.
Q 25How does Amber Volakis, Wilson's girlfriend, die in the season four finale?
A bus crash
Amber was on a bus that crashed; her damaged kidneys could not clear the amantadine she had taken, and House, a fellow passenger, cannot remember why he was there. The two-parter is House's Head and Wilson's Heart.
Q 26Where does House spend the two-hour season six premiere, Broken?
A psychiatric hospital
He checks into Mayfield Psychiatric Hospital to detox from Vicodin after hallucinating Amber and Kutner at the end of season five.
Q 27What does House do to Cuddy's home in the season seven finale of House?
Drives his car into her living room
Drives his car into her living room in anger after Cuddy ended their relationship over his addiction; the stunt lands him in prison at the start of season eight.
Q 28Which team member takes over as head of the hospital in the final season?
Foreman
Chase ends the series running the Department of Diagnostic Medicine that House left behind.
Q 29What is the title of the series finale?
Everybody Dies
Everybody Dies, directed by David Shore, bookends the pilot's alternate title, Everybody Lies; the retrospective Swan Song aired just before it on May 21, 2012.
Q 30How does House escape his troubles in the finale?
He fakes his death in a fire
He swaps dental records with a dead patient so he can spend Wilson's last months riding motorcycles with him.